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Module 4: Validation of Probabilistic Genotyping Systems for Casework Usage (Webinar)

Event Dates
This is Module 4 of the Probabilistic Genotyping Webinar Series.

The Scientific Working Group on DNA Analysis Methods (SWGDAM) and other bodies have published guidelines that specify empirical studies to be performed to assess reliability, identify limitations and develop suitable usage conditions for probabilistic genotyping systems.

In this installment of the web series Probabilistic Genotyping of Evidentiary DNA Typing Results, we discuss the intent of each validation requirement and provide examples of their execution, as well as resulting data and how they can be used to develop standard operating procedures within the forensic DNA testing laboratory.

Detailed Learning Objectives:
- Appraise developmental validation studies and construct an internal validation plan based on the SWGDAM Guidelines for the Validation of Probabilistic Genotyping Systems
- Evaluate experimental data relating to hypothesis testing, precision, repeatability, sensitivity, specificity, various numbers of contributors, contributor proportions in DNA mixtures and total DNA template amounts
- Examine validation results generated by other laboratories and learn how to relate the findings into the development of reliable standard operating procedures, with an understanding of the limitations of a probabilistic genotyping system.

- Tamyra Moretti - Federal Bureau of Investigation, Quantico, Virginia
- Sarah Noel - Laboratoire de Sciences Judiciaires et de Mdecine Legale, Montreal, Canada
- Duncan Taylor - Forensic Science South Australia, Adelaide, Australia

Date Created: February 3, 2021