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4F-MDMB-BINACA: A New Synthetic Cannabinoid Widely Implicated in Forensic Casework

NCJ Number
Journal of Forensic Sciences Volume: 64 Issue: 5 Dated: 2019 Pages: 1451-1461
Date Published
11 pages

This is the first report regarding the characterization of the new synthetic cannabinoid 4F-MDMB-BINACA.


4F-MDMB-BINACA was first analytically confirmed in seized drug material using gas chromatography-mass spectrometry (GC-MS), liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-QTOF), and nuclear magnetic resonance (NMR) spectroscopy. Subsequent to this characterization, 4F-MD-MB-BINACA was detected in biological specimens collected as part of forensically relevant casework, including medicolegal death investigations and drug impaired driving investigations, from a variety of regions in the United States. Further analysis of biological specimens resulted in the identification of the metabolites 4F-MDMB-BINACA 3,3-dimethylbutanoic acid and 4-OH-MDMB-BINACA. 4F-MDMB-BINACA is appearing with increasing frequency as a contributory factor in deaths, creating morbidity and mortality risks for drug users. Laboratories must be aware of its presence and impact, incorporating 4F-MDMB=BINACA into workflows for detection and confirmation. (publisher abstract modified)

Date Published: January 1, 2019