Training data provide values of y observed on subjects at known values of t. Models relating the mean and variance of y to t can be formulated as mixed (fixed and random) models in terms of sets of functions of t, such as polynomial spline functions. A confidence set on t* can then be had as those hypothetical values of t for which y* is not detected as an outlier when compared to the model fit to the training data. With nonconstant variance, the p-values for these tests are approximate. (Publisher abstract modified)
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