Forensic Informativity of ~3000 bp of Coding Sequence of Domestic Dog mtDNA

• NCJ Number: 245998
• Journal: Journal of Forensic Sciences Volume: 59 Issue: 4 Dated: July 2014 Pages: 898-908
• Author(s): Helen Angleby; Mattias Oskarsson Ph.D.; Junfeng Pang Ph.D.; Ya-ping Zhang Ph.D.; Thomas Leitner Ph.D.; Caitlyn Braham B.S.; Lars Arvestad Ph.D.; Joakim Lundeberg Ph.D.; Kristen M. Webb Ph.D.; Peter Savolainen Ph.D.
• Date Published: July 2014
• Length: 11 pages
• Publication Format: Article
• Publication Type: Report (Study/Research)
• Language: English
• Country: United States of America

Annotation

The discriminatory power of the noncoding control region (CR) of domestic dog mitochondrial DNA alone is relatively low.

Abstract

The discriminatory power of the noncoding control region (CR) of domestic dog mitochondrial DNA alone is relatively low. The extent to which the discriminatory power could be increased by analyzing additional highly variable coding regions of the mitochondrial genome (mtGenome) was therefore investigated. Genetic variability across the mtGenome was evaluated by phylogenetic analysis, and the three most variable ~1 kb coding regions identified. We then sampled 100 Swedish dogs to represent breeds in accordance with their frequency in the Swedish population. A previously published dataset of 59 dog mtGenomes collected in the United States was also analyzed. Inclusion of the three coding regions increased the exclusion capacity considerably for the Swedish sample, from 0.920 for the CR alone to 0.964 for all four regions. The number of mtDNA types among all 159 dogs increased from 41 to 72, the four most frequent CR haplotypes being resolved into 22 different haplotypes. Abstract published by arrangement with Wiley.