This paper summarizes quantitative electrophysiological (QEEG) research on cocaine dependence conducted at Brain Research Laboratories of New York University Medical Center.
The studies demonstrated cocaine-dependent subjects in the withdrawal state (without dependence on any other substance) had replicable abnormalities in brain function when evaluated at baseline approximately 5 to 10 days after last crack cocaine use. These abnormalities were characterized by significant excess of relative alpha power and deficit of absolute and relative delta and theta power. Abnormalities were greater in anterior than in posterior regions, and disturbances in interhemispheric relationships were also observed. In addition, QEEG subtypes were identified within the population of cocaine-dependent subjects at baseline, and these subtypes were significantly related to subsequent length of stay in treatment. The relationship between QEEG findings and the neuropharmacology of cocaine dependence is discussed. 57 references, 1 table, and 1 figure
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