Using population genetics criteria for SNPs for individual identification (IISNPs) – SNPs having nearly maximum informativeness in populations from all parts of the world – on a reduced screening panel of 31 populations, those most likely to be forensically relevant, we have identified a panel of 108 candidate SNPs that meet our operationalized criteria of an Fst <0.06 and average heterozygosity >0.40. Some of these candidate SNPs are molecularly close and/or genetically linked making them unsuitable for studies involving relationships. However, it is appropriate to keep all these markers among the candidates until they can be evaluated by laboratory and other criteria. We still advocate screening more SNPs to assure identifying a sufficient number meeting broad forensic criteria. We also believe that all of the near-final candidates should be evaluated on multiple, additional populations so that reasonably small (e.g. <10−12) genotype frequencies can be demonstrated to occur even more broadly among world populations. (Publisher abstract provided.)
Downloads
Similar Publications
- New Technique for Synthesizing Concurrent Dual-Band Impedance-Matching Filtering Networks and 0.18-μm SiGe BiCMOS 25.5/37-GHz Concurrent Dual-Band Power Amplifier
- A 10-67-GHz CMOS Dual-Function Switching Attenuator With Improved Flatness and Large Attenuation Range
- Analysis of Coordinated Denial-of-Service Attacks in IEEE 802.22 Networks