Using population genetics criteria for SNPs for individual identification (IISNPs) – SNPs having nearly maximum informativeness in populations from all parts of the world – on a reduced screening panel of 31 populations, those most likely to be forensically relevant, we have identified a panel of 108 candidate SNPs that meet our operationalized criteria of an Fst <0.06 and average heterozygosity >0.40. Some of these candidate SNPs are molecularly close and/or genetically linked making them unsuitable for studies involving relationships. However, it is appropriate to keep all these markers among the candidates until they can be evaluated by laboratory and other criteria. We still advocate screening more SNPs to assure identifying a sufficient number meeting broad forensic criteria. We also believe that all of the near-final candidates should be evaluated on multiple, additional populations so that reasonably small (e.g. <10−12) genotype frequencies can be demonstrated to occur even more broadly among world populations. (Publisher abstract provided.)
SNPs for Individual Identification
NCJ Number
255391
Journal
Forensic Science International: Genetics: Genetics Supplement Series Volume: 1 Dated: 2008 Pages: 479-481
Date Published
2008
Length
3 pages
Abstract
Date Published: January 1, 2008