U.S. flag

An official website of the United States government, Department of Justice.

Burden of Neurodegenerative Diseases in a Cohort of Medical Examiner Subjects

NCJ Number
231210
Journal
Journal of Forensic Sciences Volume: 55 Issue: 3 Dated: May 2010 Pages: 642-645
Author(s)
Kunihiro Uryu, Ph.D.; Terri Haddix, M.D.; John Robinson, B.S.; Hanae Nakashima-Yasuda,M.D., Ph.D.; Virgina M.-Y. Lee, Ph.D.; John Q. Trojanowski, M.D., Ph.D.
Date Published
May 2010
Length
4 pages
Annotation

This article reports studies of the burden of neurodegenerative neuropathologies in a cohort of Medical Examiner (ME) subjects from the County of Santa Clara (California) to determine if this unique population of decedents manifested evidence of neurodegeneration that might underlie causes of death seen in an ME practice.

Abstract

The study found that 13 percent of the brains from ME cases showed significant tau pathology, including 55 percent of those 65 years old and older and 63 percent of those 70 years old and older. The histochemical and immunohistochemical findings were consistent with Alzheimer's disease (AD) in seven subjects and frontotemporal lobar degeneration (FTLD) tauopathy type in six cases. There were no cases of Parkinson's disease, dementia with Lewy Bodies or other neurodegenerative conditions. Our study suggests that decedents older than 65 years of age in an ME practice are afflicted by common causes of dementia such as AD and FTLD, which could contribute wholly or in part to their causes of death. 1 table and 15 references (Published Abstract)

Date Published: May 1, 2010