This research introduced a new likelihood ratio method for evaluating mixed Y-STR profiles that is based on the premise that, given a haplotype has been seen in the person of interest, the most likely source of a second haplotype, matching at all or most loci, is in an individual with a recent common ancestor.
The researchers call the new method the "Haplotype centered" (HC) method for likelihood ratio derivation. For single source, unambiguous haplotypes, the HC method performs identically with the Kappa method proposed by Brenner. Analysis of mixtures requires assignment of a probability to many haplotypes seen neither in the database nor any person typed in the case. A likelihood ratio formula is derived in a way that allows a locus by locus approach. The current research demonstrates the application of the HC method on a series of Y-STR mixtures originating from two to four individuals in a manner that is still calculated locus-by-locus in nature. (publisher abstract modified)
- Fighting the Uphill War Against Illicit Drugs and Overdose Deaths: Detecting Emerging Designer Drugs and Opioid Analogs
- MPrESS: An R-Package for Accurately Predicting Power for Comparisons of 16S rRNA Microbiome Taxa Distributions including Simulation by Dirichlet Mixture Modeling
- An illustration of the effect of various sources of uncertainty on DNA likelihood ratio calculations