This article examines research into what effects solvent chemistry has on analytes being detected using electrospray ionization in ion mobility mass spectrometers.
The present work highlights the effect that solvent chemistry has on analytes being detected when utilizing electrospray ionization in ion mobility mass spectrometers. Various studies were conducted involving both positive and negative mode ionization. The enhancements observed by utilizing different levels of acid modifiers as well as the different ionic species of analytes being formed and detected are presented. The makeup of the electrospray solvent determined whether the ionic species would be protonated, sodium adducted, ammonium adducted, proton abstracted or chlorinated. Addition of solvent modifiers such as acids in the positive mode, and organic halides in the negative mode improved signal strength of analytes as well as improved spray characteristics that also decreased signal variability. The ability to perform simultaneous ionization of complex mixtures was also demonstrated through the use of solvent modifiers thereby allowing electrospray ionization ion mobility mass spectrometry the ability to simultaneously analyze complicated mixtures very quickly (millisecond separations). (Published Abstract Provided)
Downloads
Similar Publications
- Restoring Promise: Positive Research Results from a Program that Aims to Transform Correctional Culture
- Two-Stage Approach for the Inference of the Source of High-Dimension and Complex Chemical Data in Forensic Science
- Drug Use as a Predictor of Rearrest or Failure to Appear: A User's Guide to the Machine-Readable Files and Documentation, Original Instruments, and Codebook