In a group of 211 patients seeking treatment for a substance use disorder, 25 percent screened positive for hypersexual behavior. This prevalence rate greatly exceeds the estimates of hypersexual behavior found to be roughly 3-6 percent among the general population. Findings suggest that hypersexual behaviors may be more commonly observed in substance use disorder populations. Patients seeking treatment for a substance use disorder should be systematically screened for hypersexual behavior with the goal of optimizing the treatment approach. Abstract published by arrangement with Taylor and Francis.