LSD and 9,10-dihydro-LSD Analyses in Street Drug Blotter Samples via Easy Ambient Sonic-Spray Ionization Mass Spectrometry (EASI-MS)

• NCJ Number: 242059
• Journal: Journal of Forensic Sciences Volume: 57 Issue: 5 Dated: September 2012 Pages: 1307-1312
• Author(s): Wanderson Romao, Ph.D.; Bruno D. Sabino, Ph.D.; Maria Izabel M.S. Bueno, Ph.D.; Boniek G. Vaz, Ph.D.; Amadeu C. Junior, M.Sc.; Adriano O. Maldaner, Ph.D.; Eustaquio V.R. de Castro, Ph.D.; Rogerio A. Lordeiro, M.Sc.; Clesia C. Nascentes, Ph.D.; Marcos N. Eberlin, Ph.D.; Rodinei Augusti, Ph.D.
• Date Published: September 2012
• Length: 6 pages
• Publication Format: Article
• Publication Type: Report (Technical)
• Language: English
• Country: United States of America

Annotation

Normally, the identification of the LSD drug is performed by forensic laboratories, using the Ehrlich spot test.

Abstract

Normally, the identification of the LSD drug is performed by forensic laboratories, using the Ehrlich spot test. However, this is a nonspecific analysis. Additionally, the Brazilian Federal Police has identified the presence of a new compound in seized blotters: 9,10-dihydro-LSD, an uncontrolled substance. In this work, easy ambient sonic-spray ionization mass spectrometry in the positive ion mode, EASI(+)-MS, was used to characterize LSD and 9,10-dihydro-LSD compositions directly from the surface of blotters. The presence of LSD in the seized blotter samples were also confirmed via high-performance liquid chromatography with ultraviolet detector. In a set of 41 blotters analyzed by EASI(+)-MS, 28 showed positive results for LSD, 7 for 9,10-dihydro-LSD, and another 6 samples showed negative results for both LSD and 9,10-dihydro-LSD. The combination of thin layer chromatography with EASI-MS also demonstrated to be a relatively simple and powerful screening tool for forensic analysis of street drugs. Abstract published by arrangement with John Wiley & Sons.