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Population Genetics of 17 Microsatellite Loci in Three Major Groups of Andhra Pradesh, India

NCJ Number
218663
Author(s)
G. Hima Bindu; Rajni Trivedi; V. K. Kashyap
Date Published
April 2005
Length
4 pages
Annotation
This study sought to establish a database of three upper caste groups or populations of Andhra Pradesh, India in order to harness various genetic systems for match probability in human identification, population genetics, evolutionary, and disease management.
Abstract
Polymorphisms at 15 tetrameric short tandem repeat loci and 2 pentameric short tandem repeat genetic loci, Penta D and Penta E were determined in 276 people belonging to 3 predominant caste populations of Andhra Pradesh, India. All the loci were found to be highly polymorphic in all studied populations (Brahmins, Komati, and Raju). No significant deviations from the Hardy-Weinberg expectations were observed with exceptions at three loci. The discriminatory potential of the 17 short tandem repeat loci revealed Penta E and FGA to be the most informative loci in studied populations. This is the first study reporting polymorphisms at the 2 newly introduced tertrameric nucleotides, D2S1338 and D19S433, 13 core CODIS loci, and 2 pentameric loci in the studied populations. Evaluation of the forensic applicability of the 17 short tandem repeat loci, the genotype distributions and allele frequencies, and various statistical parameters would contribute to the database of global populations and increase the international short tandem repeat database of global populations. India is the second most populous country in the world and has populations with distinct ethnicity, culture, and religions. Databases for the diverse populations of this region where these genetic systems can be harnessed for match probability in human identification, population genetics, evolutionary, and disease management are essential. This study attempts to establish a database of upper caste groups of Andhra Pradesh, India. It describes the allele frequencies and the measure of forensic parameters for the 17 short tandem repeat loci in a sample of 276 unrelated people. References