U.S. flag

An official website of the United States government, Department of Justice.

NCJRS Virtual Library

The Virtual Library houses over 235,000 criminal justice resources, including all known OJP works.
Click here to search the NCJRS Virtual Library

Speciation effects of solvent chemistry on the analysis of drugs and explosives by Electrospray Ion Mobility Mass Spectrometry

NCJ Number
International Journal of Ion Mobility Spectrometry Volume: 16 Dated: 2013 Pages: 237-246
Howard Holness; Jose R. Almirall
Date Published
10 pages

This article examines research into what effects solvent chemistry has on analytes being detected using electrospray ionization in ion mobility mass spectrometers.


The present work highlights the effect that solvent chemistry has on analytes being detected when utilizing electrospray ionization in ion mobility mass spectrometers. Various studies were conducted involving both positive and negative mode ionization. The enhancements observed by utilizing different levels of acid modifiers as well as the different ionic species of analytes being formed and detected are presented. The makeup of the electrospray solvent determined whether the ionic species would be protonated, sodium adducted, ammonium adducted, proton abstracted or chlorinated. Addition of solvent modifiers such as acids in the positive mode, and organic halides in the negative mode improved signal strength of analytes as well as improved spray characteristics that also decreased signal variability. The ability to perform simultaneous ionization of complex mixtures was also demonstrated through the use of solvent modifiers thereby allowing electrospray ionization ion mobility mass spectrometry the ability to simultaneously analyze complicated mixtures very quickly (millisecond separations). (Published Abstract Provided)