Mitochondrial DNA analysis has proven to be an invaluable tool for victim identification from mass disasters and missing persons programs to criminal casework (Isenberg, 2004). The University of North Texas Health Science Center (UNTHSC) is primarily funded by the National Institute of Justice (NIJ) for the Missing Persons Program and uses advanced DNA technologies to process unidentified human remains and the family reference samples from biological relatives for both nuclear DNA (nDNA) and mtDNA. Since most missing persons cases rely heavily on mtDNA testing of skeletal remains, mtDNA testing of reference samples is necessary for making family associations. The resulting DNA profiles are uploaded to the Missing Persons Index database. In this database, mtDNA and nDNA profiles from the unidentified remains can be searched against the biological family reference profiles and associations are recommended through kinship analysis testing. There are several hundred thousand missing persons cases reported each year and there are more than 14,000 unidentified human skeletal remains retained in medical examiners' and coroners' offices nationwide (Rhonda K. Roby et al., 2007). These numbers alone demonstrate the throughput requirements needed for DNA processing.
Downloads
Similar Publications
- A Systematic Study of Liquid Chromatography to Separate Eighteen Natural Cannabinoids for Potency Testing of Hemp-Based Products Using Diode Array Detector and Electrospray Ionization Mass Spectrometry
- Gas chromatography with dual cold electron ionization mass spectrometry and vacuum ultraviolet detection for the analysis of phenylethylamine analogues
- NIST 3D Ballistics Research Database Goes Live