Based on the data, time-course trend plots, geographic distribution heat maps, and emerging opioids were presented in reports. These reports were produced every 3 months for distribution within the public health, criminal justice, and forensic science communities. This provides timely and updated information on opioid trends in the United States. Throughout 2018 and into 2019, this project was able to report within days of the close of each quarter that fentanyl positivity steadily increased while heroin positivity remained relatively stable. Combining seized drug and analytical toxicological intelligence data substantially reduced the lag time between new identifications of the drugs available on the street and their detection in toxicological (postmortem and DUID) cases. Resources should be regularly allocated to sustain this approach to monitoring U.S. drug markets.