DETERMINATION OF METHAQUALONE IN URINE BY METABOLITE DETECTION VIA GAS CHROMATOGRAPHY

• NCJ Number: 32529
• Journal: Journal of Forensic Sciences Volume: 21 Issue: 1 Dated: (JANUARY 1976) Pages: 98-107
• Author(s): R C PERMISOHN; L R HILPERT; L KAZYAK
• Date Published: 1976
• Length: 10 pages
• Corporate Author: American Soc for Testing and Materials
• Publication Format: Article
• Language: English
• Country: United States of America

Annotation

THIS STUDY SHOWS THAT METHAQUALONE RAPIDLY UNDERGOES BIOTRANSFORMATION TO MONOHYDROXYLATED METABOLITES, AND CONCENTRATIONS OF METABOLITES IN URINE ARE MANY TIMES GREATER THAN THE UNCHANGED DRUG.

Abstract

DRUGS AT SUBMICROGRAM CONCENTRATIONS ARE OFTEN DIFFICULT TO DISCERN FROM EXTRANEOUS MATERIALS, AND INTERFERENCES FROM NORMAL URINARY CONSTITUENTS COMPLICATE THE ANALYSIS. RETENTION INDEXES OF BLANK URINE CONSTITUENTS AND METHAQUALONE ARE SO CLOSE THAT INTERPRETATION OF Q QUANTITATIVE AND EVEN QUALITATIVE DATA AT THESE LOW CONCENTRATIONS IS SUBJECT TO CONSIDERABLE ERROR. GAS CHROMATOGRAPHIC SEPARATION OF MONOHYDROXYLATED METABOLITES OF METHAQUALONE FROM URINARY INTERFERENCES HAS BEEN DEMONSTRATED; METABOLITE PATTERNS HAVE BEEN CHARACTERIZED AND RECOGNIZED AS IMPORTANT FOR THE IDENTIFICATION OF METHAQUALONE INGESTION. (THE DRUG METHAQUALONE IS COMMONLY REFERRED TO AS QUAALUDE, SOPOR, PAREST, OR MANDRAX - ALL OF WHICH ARE COPYRIGHTED TRADE NAMES). (AUTHOR ABSTRACT)