NCJ Number
222073
Journal
Forensic Science International: Genetics Volume: 2 Issue: 2 Dated: March 2008 Pages: 134-137
Date Published
March 2008
Length
4 pages
Annotation
This study examined the nature and the time of origin of the duplication that is responsible for the tri-allelic TPOX genotypes in the African populations.
Abstract
The fact that a variety of bi-allelic combinations were transmitted to tri-allelic offspring suggests that the duplicated allele is not close to the TPOX locus. Also, there was apparent linkage equilibrium between the duplication locus and the main TPOX locus. The excess of tri-allelic females and the finding that tri-allelic males never transmit two alleles (alternative genes) to their sons but always transmit two alleles to their daughters strongly suggests that the duplicated allele is on an X chromosome. Approximately 2.4 percent of indigenous South Africans have three rather than two TPOX alleles. This study attempted to shed light on the nature and time of origin of the duplication responsible for the commonly observed tri-allelic TPOX genotypes in the South African population. Tables, figure, references