NCJ Number
142429
Journal
Japanese Journal of Legal Medicine Volume: 43 Issue: 5 Dated: (October 1989) Pages: 424-429
Date Published
1989
Length
6 pages
Annotation
This study found that the potentiation of CO2 gas for hypoxic hypoxia-induced death plays an important role in the hypercapnic hypoxia-induced death.
Abstract
The circumstances in the hypoxic death cases are generally classified into pure hypoxic condition as replacement of O2 gas with N2 gas and hypercapnic hypoxic condition as replacement of O2 gas with CO2 gas. Although pure hypoxia and hypercapnic hypoxia should be distinguished, there are very few reports and data on their distinctive research. To assess the toxicity of both hypoxic gases in male mice, the researchers determined the interaction range of O2 and CO2 gas concentrations, measured the spontaneous motility of mice exposed to various gases, and investigated the effect of CO2 gas on the hypoxic hypoxia-induced death. Gas toxicity was evaluated by the median lethal concentration of O2 during 10 minutes exposure to the gases, using a self-made simple experimental apparatus for acute inhalation gas toxicity. The potentiation of CO2 occurred in the range of 6 percent to 12 percent of O2 concentration. The results indicate that the potentiation of CO2 gas for hypoxic hypoxia-induced death plays an important role in the hypercapnic hypoxia-induced death. 3 figures and 24 references