Since many correctional facilities are providing early release to eliminate crowding that facilitates the spread of COVID-19, it is important that these facilities provide prerelease instructions to inmates about the basics of preventing infection and transmission of COVID-19 while in custody and upon release. A significant percentage of inmates have low reading comprehension, a deficit in health education, and exposure to misinformation about the nature and prevention of COVID-19. The current report guides correctional staff in the content and delivery of information to inmates on the nature of the virus, the risks and symptoms of its infection, and ways to protect against it and prevent its spread. Inmates with risk factors, such as age and pre-existing health conditions that increase vulnerability to and severity of the virus infection, should be made aware of their increased risk and receive intensive instruction in preventive methods. Handouts with various instructions related to prevention and response to COVID-19 infection are provided for reproduction. Accessible videos cover such issues as handwashing, social distancing, shelter-in-place, and cough etiquette.