This research presents using Hidden Markov Models to resolve DNA basecalling problems.
This paper proposes Hidden Markov Models (HMMs) as an approach to the DNA basecalling problem. The authors model the state emission densities using Artificial Neural Networks, and provide a modified Baum-Welch re-estimation procedure to perform training. Moreover, the authors develop a method that exploits consensus sequences to label training data, thus minimizing the need for hand-labeling. The results demonstrate the potential of these models and suggest further research. The authors also perform a careful study of the basecalling errors and propose alternative HMM topologies that might further improve performance. The authors conclude by suggesting further research directions.
Similar Publications
- Tablets behind bars: evidence from a staggered adoption difference-in-differences study of prison misconduct
- Developmental Variation in Amygdala Volumes: Modeling Differences Across Time, Age, and Puberty
- Insights into turning points from the perspective of young people with out-of-home care experience: events, impact and facilitators of change