This report was prepared by the United Nations Office on Drugs and Crime (UNODC) and presents an outline of the Office's activities for 2011. The work of the UNODC falls under its regional and thematic programs: drug control; combating transnational organized crime, corruption, and terrorism; criminal justice; and research, trend analysis, and scientific and forensic support. The report begins with an introduction of the work of UNODC and its strategic orientation. This is followed by a review of the regional cooperation initiatives of UNODC. The regions discussed were the African states, including measures to support African states in their efforts to combat the world drug problem, West and Central Asian states, Arab states, Latin American and Caribbean states, South-Eastern European states, and Asian and Pacific states. The third section of the report discusses UNODC's efforts on drug control that deal with sustainable livelihoods, supply reduction, drug demand reduction, treatment, and rehabilitation, and new and emerging issues. The fourth section covers UNODC's efforts to combat transnational organized crime, corruption, and terrorism including trafficking in persons and smuggling of migrants, corruption, and international cooperation against terrorism. The fifth section discusses UNODC's efforts on crime prevention and criminal justice, while the sixth section covers the Office's efforts in research, trend analysis, and scientific and forensic support. The seventh section covers efforts to strengthen the work of UNODC, while the eighth section presents a set of recommendations for member states to consider when dealing with drug control, transnational organized crime, corruption, and terrorism, and criminal justice reform.